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BIOCHEMISTRY
Topic list of End-Semester Exam Faculty of Pharmacy
2011/12 2nd semester

  1. Thermodynamics of biochemical pathways
  2. Functions of proteins in the living organism, the chemical nature of proteins
  3. Formation and characterization of three dimensional structure of proteins
  4. Molecular mechanism of enzyme catalysis
  5. Coenzymes and their actions
  6. Classification of enzymes
  7. Isoenzymes, multienzyme systems, units of enzyme activity, enzyme regulation
  8. Kinetics of enzyme reactions
  9. Glycolysis and its regulation
  10. Glycogenesis and glycogenolysis , their regulation
  11. Gluconeogenesis, hexose monophosphate shunt
  12. Relationship between the carbohydrate metabolism and other metabolisms
  13. Degradation of fatty acids and its energy balance
  14. Synthesis of saturated fatty acids, eicosanoids
  15. Synthesis of neutral lipids and phospholipids
  16. Synthesis of cholesterol
  17. Ketone bodies
  18. Removal of amino acid nitrogen
  19. Urea cycle and its importance
  20. The fate of the carbon skeleton of amino acids
  21. The role of amino acids in the synthesis of functional compounds containing nitrogen
  22. Source, transport and utilization of C1 groups
  23. Metabolism of nucleotides, participation in the synthesis of biologically functional compounds
  24. Diseases associated with abnormal nucleotid metabolism, compounds influencing on the nucleotide metabolism
  25. Citric acid cycle, its regulation and importance
  26. Electron transport chain; its energetics and inhibitors
  27. Oxidative phosphorylation, effects of uncouplers
  28. Blood plasma proteins and their functions
  29. Biochemistry of red blood cells, molecular mechanism of oxygen transport
  30. Biochemistry of leukocytes
  31. Biochemical base of blood clotting and fibrinolysis
  32. Structure and function of biological membrane, dynamics of membrane components
  33. Transport across the membrane
  34. Metabolism and energy source of muscle, muscle diseases
  35. Molecular mechanism and regulation of muscle contraction
  36. The role of liver in the metabolism
  37. Mechanism of biotransformation
  38. Biochemical effects of alcohols
  39. The role of quantitative composition of nutrients, macronutrients
  40. The role of quantitative composition of nutrients, micronutrients and dietary fibres
  41. Metabolism of central nervous system
  42. Neurotransmitter receptors and the forms of synaptic transmission
  43. Synthesis and inactivation of neurotransmitter
  44. Fibrillar proteins of extracellular matrix, types and characteristics of proteoglycans
  45. Components of cytoskeleton and their importance, importance of cell adhesion
  46. Biochemistry of hypotalamo and hypophyseale hormone system
  47. Hormon synthesis in thyroid gland, biochemical effect of thyroid hormones, and Ca2+ homeostasis
  48. Hormonal regulation of blood glucose level, biochemical consequence of diabetes mellitus
  49. Synthesis of steroid hormones and their effects
  50. The structure of DNA, the structure of chromosome, euchromatin, heterochromatin, regulation of transcription, enhancer, silencer, the difference between prokariotic and eukaryotic gene expression
  51. RNA types, RNA polymerases, the transcription process, maturation of mRNA, mechanism of splicing, tissue specific and development dependent splicing, thalassemias, antisense RNA
  52. Types and importance of signalling pathways
  53. Involvement of signalling pathways in the regulation of metabolism
  54. Regulation of metabolism at the organ level: metabolic adaptation in stress, physical exercise, pregnancy, lactation
  55. Regulation of metabolism at the organ level: metabolic adaptation in starvation and well-fed state